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...However, the Hungarian scientist who influenced my scientific way of thinking is Emeritus Professor Laszlo Endrenyi of the University of Toronto. He also holds an honorary doctorate (DHC) from the Semmelweis University. I cited, in one of my first papers (Panos Macheras, Quick method for the calculation of the absorption rate constant of the linear one-compartment model using all available blood level data. International Journal of Pharmaceutics, 19: 339-343 (1984)), his work on the robust parameter estimation of a simple kinetic model (L. Endrenyi, H. Y. Tang (1980). Robust parameter estimation of a simple kinetic model. Comp. Biomed. Res., 13: 430-436). A few years later he invited me to Toronto and I gave a lecture in November 1988 while working at the University of Michigan as a Visiting Associate Professor. The title of my talk was Quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept, 11 November 1988. This talk was published later on, P. Macheras, M. Symillides, Toward a quantitative approach for the prediction of the fraction of dose absorbed using the absorption potential concept. Biopharmaceutics and Drug Disposition, 10: 43-53 (1989). This visit was the start of a continuous interaction in studies dealing with oral drug absorption and bioequivalence. As an example, I refer to the improvement (P. Macheras, M. Symillides. C. Reppas (1996). An improved intercept method for the assessment of absorption rate in bioequivalence studies. Pharmaceutical Research, 13(11): 1755-1758) of his method (Endrenyi L., Al-Shaikh P. (1995). Sensitive and specific determination of the equivalence of absorption rates. Pharmaceutical Research, 12(12): 1856-1864) on the use of a metric for the assessment of equivalence of absorption rates. Laszlo was always and still is a prototype model for me. I used to say that wise people like Laszlo think differently than the average person. We have met up with him in many congresses organized in Athens (Greece), Budapest (Hungary), and many cities in the USA. Through the years we developed a genuine friendship for which I am proud of."

L. Endrenyi card with a request for a 1985 reprint

Invitation Letter from Laszlo to Panos for an invited lecture to the University of Toronto